Proximity Effects on the Protein Domain Level: Engineering Prolyl Isomerases through Combinatorial Biochemistry
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چکیده
منابع مشابه
Proximity effects on the protein domain level: engineering prolyl isomerases through combinatorial biochemistry.
Peptidyl isomerases (PPIs) catalyze the backbone trans to cis interconversion of AA–Pro (AA: amino acid residue that precedes Pro) bonds. This reaction is particularly important for folding proteins since only proper cis-Pro configuration at certain (rather rare) key positions allows for attaining the native and thus functional three-dimensional structure. While some PPIs, such as FKBP12, recog...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2013
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2013.07.031